I've been living in Cusco for over four months now and it's fair to say I like to let my hair down and sample the Cusco nightlife sometimes. I haven't visited all the bars and clubs yet, and I probably never will, but here's a few that I've enjoyed so far.
Ukukus is one of my favorite Cusco clubs and it can be found on Plateros just off the main Plaza. I like Ukukus because it attracts as many locals as tourists and usually has a good atmosphere. Most nights they start off with live music from local bands, then the disco usually starts around 11 pm. They always play a varied selection of music from latin to pop & rock and then many different styles of dance. You can also play online casino here.
Mama Africa is very popular with the tourists and is packed full most nights. If you like to feel hot and sweaty and squashed then this is a great place to be. It also seems to be a good place to cop off with the opposite sex if that's what you're looking for. Watch out for the Bracero/as though!
I've been to Inca Team a few times and always had fun, although like Mama Africa it's often jam-packed (at least during high tourist season). If you like to do nothing but dance the night away this is probably the best place to come. Inca Team can be found on the corner of Plaza de Armas.
Located right next to Inca Team this is another very popular Cusco club. I've only been here a couple of times but I had fun on both occasions
Mythology, Inca Team, and Mama Africa are basically right next to each other. You don't have to pay to enter any of them so you can easily check them all out on a single night and see which works best for you. They all play similar music usually and drink prices are about the same.
I haven't been in here yet, but by most accounts, it's a very popular and funky lounge bar with great music and cocktails. I'll be visiting shortly.
No prizes for guessing that Paddy is an Irish pub. It can get very lively in the evenings. I was disappointed to find that Guinness is only available in a can and is very expensive.
Norton Rat's Tavern
This is a large pub on a first floor overlooking the Plaza de Armas. It has a pretty good selection of beer and the food is cheap and reasonable. There's also several games available in form of pool and darts.
The Cross Keys
An English pub that usually features a good selection of beers. It's a popular haunt for travelers and expats looking for a taste of home.
The Real McCoy
Another English-style pub, just off the Plaza de Armas. I haven't been here in the evening yet, but I've been in several times during the day with my laptop because they have really fast free wifi. The food is pretty reasonable and they also have a large LCD screen showing sport and particularly British football games.
This has got to the be the most far out bar/restaurant in Cusco (and possibly the world!) and everyone seems to have a different opinion about whether it works. But if crazy art, glitter balls, cracked mirrors and angel statues are your thing, you'll feel right at home in Fallen Angel.